The meeting on 19 October brought together the foreign ministers of Uzbekistan, Kazakhstan, Kyrgyzstan, Tajikistan and Turkmenistan alongside Rubio.
In a joint statement issued after the meeting, the ministers said their governments attached particular importance to combating terrorism and transnational organised crime and strengthening border security.
However, despite repeated concerns from Central Asian countries about terrorist threats and the activities of extremist groups in Afghanistan, the joint statement from the Samarkand meeting made no direct reference to Afghanistan or the Taliban.
The statement said cooperation between the United States and Central Asian countries would be expanded to tackle illegal migration, human trafficking, drug trafficking and arms smuggling.
The two sides also emphasised stronger cybersecurity cooperation and efforts to counter digital threats and cybercrime.
Elsewhere in the statement, member countries stressed greater cooperation on nuclear security, the protection of nuclear materials and the peaceful use of nuclear energy.
Expanding Economic and Trade Cooperation
The joint statement said the United States and Central Asian countries would work together to expand trade and investment, strengthen transport connectivity and develop the Trans-Caspian trade route.
The cooperation is intended to increase bilateral and intra-regional trade, simplify customs procedures and promote a competitive market in Central Asia.
The two sides also emphasised expanding cooperation in energy, mineral extraction and processing, and developing high-value supply chains.
According to the statement, member countries aim to use their natural resources and technological capacity to support economic growth, increase exports and create new business opportunities.
Technology development, e-commerce, English-language education and greater digital connectivity were also identified as areas of cooperation between the United States and Central Asian countries.
Rubio Holds Bilateral Talks With Regional Foreign Ministers
Following his meetings with Central Asian foreign ministers, Rubio said cooperation between Washington and countries in the region could create new business opportunities, strengthen economies and contribute to greater regional security.
Rubio also said he held a separate meeting with Uzbekistan’s Foreign Minister Bakhtiyor Saidov.
According to Rubio, the two discussed expanding the strategic partnership between Washington and Tashkent, including cooperation on infrastructure, space technology, critical minerals and the C5+1 framework.
The US secretary of state also emphasised expanding bilateral economic and security cooperation during a meeting with Kazakhstan’s foreign minister.
He thanked Kazakhstan for supporting peace initiatives by the Donald Trump administration, including the Abraham Accords.
Sergio Gor, the US ambassador to India and special envoy for South and Central Asian affairs, said Rubio’s meetings with regional foreign ministers focused on Washington’s commitment to supporting the sovereignty of Central Asian countries, energy security and stronger supply-chain resilience.
What Is the C5+1 Mechanism?
The Samarkand meeting was held under the C5+1 mechanism, a framework established in 2015 between the United States and the five Central Asian countries of Uzbekistan, Kazakhstan, Tajikistan, Turkmenistan and Kyrgyzstan.
The mechanism aims to expand political, economic, trade, security and energy cooperation between the United States and countries in the region.
Afghanistan Absent From the Agenda
Afghanistan shares borders with Central Asian countries, and security developments there have contributed to regional concerns over terrorism and extremism.
Countries in the region have repeatedly expressed concern in recent years about the activities of Islamic State Khorasan Province and other armed groups in Afghanistan.
However, the joint statement from the Samarkand meeting did not identify Afghanistan as a specific area of cooperation or security concern.
Instead, it referred only to the members’ broader commitment to combating terrorism, transnational organised crime and cross-border threats.
The C5+1 framework was established in 2015 between the United States and five Central Asian countries to expand political, economic, security and energy cooperation between Washington and the region.